Iodine chloride → HCID 490385, compound

HRID 732919Notes

Reaction equation

HRID 732919 reaction equation
ICl.[OH:3][CH2:4]C(CO)OCN1C=C(C=C)C(=O)NC1=O.[OH:20][CH2:21][CH2:22][O:23][CH2:24][N:25]1[CH:32]=[C:31]([CH:33]([N:36]=[N+:37]=[N-:38])[CH2:34][I:35])[C:29](=[O:30])[NH:28][C:26]1=[O:27]>C(Cl)(Cl)Cl.CO>[OH:20][CH2:21][CH:22]([CH2:4][OH:3])[O:23][CH2:24][N:25]1[CH:32]=[C:31]([CH:33]([N:36]=[N+:37]=[N-:38])[CH2:34][I:35])[C:29](=[O:30])[NH:28][C:26]1=[O:27]

Participants

5

Reactant 3

HCID 24640Iodine chlorideHCID 490382HCID 490382, compoundHCID 10331953HCID 10331953, compound

Product 1

HCID 490385HCID 490385, compoundYield 29.6%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Reaction of iodine monochloride (72.0 mg, 0.44 mmol) with 9a (95 mg, 0.39 mmol), using the procedure described for the preparation of 2c, and purification of the product by silica gel column chromatography using chloroform-methanol (90:10, v/v) as eluent afforded 10c as a syrup (48 mg, 29.6%).

Sources & evidence

ORD record
ord-2f605a7b239a41faaf27ffdbb7b04a95
Source dataset
uspto-grants-2009_09
Patent number
US07589077B2

Reaction notes

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