Water → 1-[4-Benzoyloxy-3-(benzoyloxymethyl)-1-butyl]-5-(1-azido-2-bromoethyl)uracil

Participants

Reaction Conditions

Reaction Steps

A mixture of 22 (510 mg, 1.14 mmol), saturated solution of sodium azide in water (300 mg, 4.6 mmol), N-bromosuccinimide (223 mg, 1.25 mmol) and 1,2-dimethoxyethane (50 ml) was stirred at 0° C. for 30 min. Removal of the solvent in vacuo gave a viscous oil which was purified by silica gel column chromatography. Elution with chloroform-methanol (96:4, v/v) yielded 23 (530 mg, 81.5%) as a syrup.

Provenance & Evidence