Hydrazine hydrate (1:1) → HCID 59888385, compound

Participants

Reaction Steps

To a stirred solution of 2-[4-(1-methyl-piperidin-4-yl)-butyl]-isoindole-1,3-dione (2.67 g, 8.89 mmol) in EtOH (50 mL) was added excess hydrazine hydrate (15 mL). After 18 h, the mixture was filtered and the filtrate was diluted with satd aq. NaHCO3 (20 mL) and water (20 mL). The mixture was extracted with CHCl3 (3×50 mL) and the combined organic layers were dried (Na2SO4) and concentrated to provide 1.36 g (90%) of a yellow oil, which was used in the next step without further purification.

Provenance & Evidence