HCID 57839057, compound → HCID 57839056, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 4-(2,4-dichlorophenyl)-6-methyl-2-phenyl-1,4-dihydropyrimidine-5-carboxylate (600 mg, 1.76 mmol) in PhCH3 (6 mL) was added MnO2 (227 mg, 2.64 mmol) and the reaction was heated to 95° C. for 14 hrs. The reaction was filtered through a pad of celite, concentrated under reduced pressure, and purified by flash chromatography (silica gel, 30% EtOAc/hexane) to give methyl 4-(2,4-dichlorophenyl)-6-methyl-2-phenylpyrimidine-5-carboxylate (150 mg, 23% for 2 steps) and 4-(2,4-dichlorophenyl)-6-methyl-2-phenylpyrimidine-5-carboxylic acid (100 mg, 15% for 2 steps).

Provenance & Evidence