Triacetoxyperiodinane → HCID 57839040, compound

Participants

Reaction Steps

To a stirred solution of (4-(2,4-dichlorophenyl)-6-methyl-2-phenylpyrimidin-5-yl)methanol (75 mg, 0.2 mmol) in CH2Cl2 (6 mL) was added Dess-Martin periodinane (102 mg, 0.24 mmol). The reaction was kept for 2 hrs and was diluted with EtOAc (10 mL). The organic layer was washed with saturated NaHCO3 solution (10 mL), and brine (10 mL), dried (MgSO4), filtered and concentrated under reduced pressure to give the crude product as a white solid (75 mg). The crude product was purified by flash chromatography (silica gel, 30% EtOAc/hexane) to give 4-(2,4-dichlorophenyl)-6-methyl-2-phenylpyrimidine-5-carbaldehyde (65 mg, 91% for 2 steps) as a white solid.

Provenance & Evidence