Diethyl Malonate → HCID 12369938, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of diethyl malonate (0.92 g, 5.71 mmol) in toluene (10 mL) was added 2,4-dichlorobenzaldehyde (1 g, 5.71 mmol), piperidine (23 μL, 0.23 mmol), acetic acid (13 μL, 0.23 mmol) and molecular sieves (3 Å). The reaction was heated to 70° C. for 2 days and was concentrated under reduced pressure. The residue was filtered through a pad of silica flushing with EtOAc/hexane (1:1) solution. The filtrate was concentrated to give diethyl 2-(2,4-dichlorobenzylidene)malonate (1.83 g, 97%) as a yellow oil.

Provenance & Evidence