2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 57839063, compound

Participants

Reaction Steps

The crude methyl 2-(benzylthio)-4-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate (0.22 mmol) from Step 1 was dissolved in CH2Cl2 (2 mL) and DDQ (50 mg, 0.22 mmol) was added. After 1 hr, The reaction was diluted with cyclohexane/EtOAc solution (4:1, 10 mL) and the organic layer was extracted with saturated NaHCO3 solution (2×6 mL), brine (5 mL). The organic layer dried (MgSO4), filtered and concentrated under reduced pressure to give methyl 2-(benzylthio)-4-(2,4-dichlorophenyl)-6-methylpyrimidine-5-carboxylate. The crude reaction product (>95% purity) was moved onto next step without further purification.

Provenance & Evidence