Thiomorpholine → HCID 57839070, compound

Participants

Reaction Steps

To a stirred solution of methyl 2-(benzylsulfonyl)-4-(2,4-dichlorophenyl)-6-methylpyrimidine-5-carboxylate (17 mg, 0.037 mmol) in dioxane (2 mL) was added thiomorpholine (4.5 mL, 0.045 mmol). After at 40° C. for 1 hr, the reaction was concentrated under reduced pressure and diluted with EtOAc (10 mL). The organic layer was extracted with saturated NaHCO3 solution (2×6 mL), brine (5 mL), dried (MgSO4), filtered and concentrated under reduced pressure to give methyl 4-(2,4-dichlorophenyl)-6-methyl-2-thiomorpholinopyrimidine-5-carboxylate (15 mg, 100%). The crude reaction product (>98% purity) was moved onto next step without further purification.

Provenance & Evidence