HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl isocyanate → 5-Amino-N-benzyl-7-(2Furyl)-3H-[1,2,3]Triazolo[4,5-D]Pyrimidin-3-Ylcarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Reactant | HCID 178508305 | HCID 178508305 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Amino-N-benzyl-7-(2Furyl)-3H-[1,2,3]Triazolo[4,5-D]Pyrimidin-3-Ylcarboxamide | HCID 9858929 | 19% |
Reaction Steps
A solution of 7-(2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine (202 mg, 1.0 mmol) in DMF (3 mL) was treated with benzyl isocyanate (123 μL, 1.0 mmol) and a catalytic amount of DMAP, stirred at room temperature overnight, diluted with EtOAc and filtered to give the title compound (62 mg, 19%) as a peach coloured solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07589097B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-d1c4c325b7d04ae1b247468ac384b8b4 |
| Source note | uspto-grants-2009_09 |