Boron tribromide → HCID 9901196, compound

HRID 732975Notes

Reaction equation

HRID 732975 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:7]2[N:15]=[N:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23]C)[CH:18]=3)[C:8]=2[N:9]=[C:10]([NH2:12])[N:11]=1.B(Br)(Br)Br>ClCCl>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:7]2[N:15]=[N:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([OH:23])[CH:18]=3)[C:8]=2[N:9]=[C:10]([NH2:12])[N:11]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 9901700HCID 9901700, compound

Product 1

HCID 9901196HCID 9901196, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 7-(2-furyl)-3-(3-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine (119 mg, 0.37 mmol) in dichloromethane (20 mL) at 0° C. was treated with boron tribromide (1-M in dichloromethane, 8.8 mL, 8.8 mmol) portion-wise over 3 days, concentrated in vacuo and isolated by filtration to give the title compound (114 mg, 100%) as a yellow solid.

Workup

  1. concentrationconcentrated in vacuo
  2. customisolated by filtration

Sources & evidence

ORD record
ord-e4ac3698ed634d1b957a016a996ef653
Source dataset
uspto-grants-2009_09
Patent number
US07589097B2

Reaction notes

Loading…