反应详情

温度

80 °C

A solution of 6-(5-methyl-2-furyl)pyrimidine-2,4,5-triamine (5.8 g, 30.1 mmol) in dioxane (116 mL) was treated with isoamyl nitrite (4.1 mL, 30.5 mmol), heated at 80° C. for 3.5 h, cooled to room temperature and the resulting precipitate was filtered, washed with dioxane (10 mL) and heptane (2×15 mL) then triturated with heptane and filtered to give the title compound (4.7 g, 77%) as a sandy solid.

1. temperaturecooled to room temperature
2. filtrationthe resulting precipitate was filtered
3. washwashed with dioxane (10 mL) and heptane (2×15 mL)
4. customthen triturated with heptane
5. filtrationfiltered