HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 2-(4-Acetamidophenoxy)-4-bromobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(4-Aminophenoxy)-4-bromobenzoic acid | HCID 57839210 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(4-Acetamidophenoxy)-4-bromobenzoic acid | HCID 66702200 | 85.7% |
Reaction Steps
Compound 2f (500 mg, 1.6 mmol) in 10 mL of THF was treated with acetyl chloride (0.15 mL, 2.08 mmol) and triethylamine (0.22 mL, 2.08 mmol). After stirring for 2.5 h the solid was collected. The filtrate was evaporated in vacuo to give 0.48 g of Compound 3f. MS m/z=331 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07589103B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-6f075223eebc4b188fd0aa3f9f682543 |
| Source note | uspto-grants-2009_09 |