tert-Butyl 2-oxopiperidine-1-carboxylate → 7-Acetylamino-9-piperidin-4-ylidene-9H-xanthene-3-carboxylic acid diethylamide

HRID 733059Notes

Reaction equation

HRID 733059 reaction equation
[CH2:1]([N:3]([CH2:21][CH3:22])[C:4]([C:6]1[CH:7]=[CH:8][C:9]2[C:10](=O)[C:11]3[C:16]([O:17][C:18]=2[CH:19]=1)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2].C([N:30]1[CH2:35][CH2:34][CH2:33][CH2:32][C:31]1=O)(OC(C)(C)C)=O>>[CH2:1]([N:3]([CH2:21][CH3:22])[C:4]([C:6]1[CH:7]=[CH:8][C:9]2[C:10](=[C:33]3[CH2:32][CH2:31][NH:30][CH2:35][CH2:34]3)[C:11]3[C:16]([O:17][C:18]=2[CH:19]=1)=[CH:15][CH:14]=[C:13]([NH:3][C:4](=[O:5])[CH3:6])[CH:12]=3)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 7577838tert-Butyl 2-oxopiperidine-1-carboxylateHCID 15953972N,N-Diethyl-9-oxo-9H-xanthene-3-carboxamide

Product 1

HCID 665467787-Acetylamino-9-piperidin-4-ylidene-9H-xanthene-3-carboxylic acid diethylamide

Procedure

Compound 10f was synthesized by an adaptation of Procedure 7, substituting compound 7f for compound 6a, and substituting N-Boc-piperidone for N-carbethoxynortropinone. MS m/z=420.3 (M+1).

Sources & evidence

ORD record
ord-07dce1c56273448c98133402c583c092
Source dataset
uspto-grants-2009_09
Patent number
US07589103B2

Reaction notes

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