Acetic Acid → 6H-Pyrrolo[2,3-b]thieno[2,3-d]pyridine-2-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 6H-1-Thia-5,6-diaza-as-indacene-2-carboxylic acid methyl ester (100 mg, 0.43 mmol), LiOH (25.5 mg, 1.07 mmol) is dissolved in THF (4 ml) and H2O (1 mL). The mixture is stirred at 60° C. for 3 hours. Acidification with acetic acid results in a brown solid which is collected by filtration. It is then dried in vacuo and used for the next step without any further purification.

Provenance & Evidence