Ethylene Glycol → Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylate

Participants

Reaction Steps

4-Oxocyclohexanecarboxylic acid ethyl ester (52.8 g, 0.31 mol, Merck, order no. 814249), ethylene glycol (67.4 g, 1.08 mol) and p-toluenesulfonic acid (0.7 g) in toluene (160 ml) were stirred for 20 h at RT, the reaction solution poured into diethyl ether (300 ml) and washed with water, sodium hydrogencarbonate solution and sodium chloride solution. The solution was dried (Na2SO4), evaporated under a vacuum and the remaining colorless liquid further processed without purification.

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