Tert-butyl 4-cyanooxane-4-carboxylate → Tert-butyl 4-(aminomethyl)oxane-4-carboxylate

Participants

Reaction Steps

A mixture of tert-butyl 4-cyanotetrahydro-2H-pyran-4-carboxylate (18.95 g, 0.0897 mol, step 1 of Example 1) and Raney Ni (1.00 g) in methanol (200 mL) was hydrogenated (3 atm) at room temperature for 12 h. Then, the mixture was filtered through a pad of Celite, and the filtrate was concentrated in vacuo to give 16.01 g (83%) of the title compound as yellow syrup.

Provenance & Evidence