tert-Butyl 4-({[(2'-oxospiro[cyclopentane-1,3'-indol]-1'(2'H)-yl)carbonyl]amino}methyl)piperidine-1-carboxylate → 2'-Oxo-N-(piperidin-4-ylmethyl)spiro[cyclopentane-1,3'-indole]-1'(2'H)-carboxamide

Participants

Reaction Steps

tert-Butyl 4-({[(2′-oxospiro[cyclopentane-1,3′-indol]-1′(2′H)-yl)carbonyl]amino}methyl)piperidine-1-carboxylate (750 mg, 1.8 mmol, step 1 of Example 2) was dissolved in 10% HCl in methanol (20 mL) and the mixture was stirred for 7 h at room temperature. Concentrated gave a colorless oil, which was chromatographed on a column of silica gel eluting with CH2Cl2/methanol/NH4OH (12/11/0.1) to give 570 mg (quant.) of the title compound as colorless oil.

Provenance & Evidence