Fumaric Acid → HCID 131727630, compound

Participants

Reaction Steps

1-{[4-({[(3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}cyclobutanecarboxylic acid (2.09 g, 5.04 mmol, Example 9) was dissolved with THF (25 mL) at 60° C. Fumaric acid (293 mg, 2.52 mmol) was added to the solution. The mixture was concentrated until 12.5 mL. It was cooled to room temperature, and stirred for 1 h. After filtration, the obtained solid was washed with THF (3 mL), and dried in vacuo. The desired compound was obtained as a white solid (2.02 g, 85%).

Provenance & Evidence