Phosphorus oxychloride → HCID 86619631, compound

Participants

Reaction Steps

A mixture of 6-propyl-4-(3-trifluoromethylphenyl)-1H-pyrimidin-2-one (204 mg) and phosphorus oxychloride (3 mL) was stirred and heated at reflux for 72 h, then allowed to cool and poured onto a mixture of ice/ether (20 mL). The ether layer was separated, washed with saturated sodium carbonate solution (20 mL), dried over sodium sulphate, and evaporated at reduced pressure to afford 2-chloro-4-propyl-6-(3-trifluoromethylphenyl)-pyrimidine as a dark brown oil (239 mg).

Provenance & Evidence