Phosphorus oxychloride → HCID 57839132, compound

Participants

Reaction Steps

A mixture of 5-methyl-6-propyl-4-(3-trifluoromethylphenyl)-1H-pyrimidin-2-one (64 mg) and phosphorus oxychloride (3 mL) was stirred and heated at reflux for 24 h, then allowed to cool and poured onto a mixture of ice/ether (20 mL). The ether layer was separated, washed with saturated sodium carbonate solution (10 mL) and water (10 mL), dried over sodium sulphate, and evaporated at reduced pressure to afford 2-chloro-5-methyl-4-propyl-6-(3-trifluoromethylphenyl)-pyrimidine as an oil (64 mg).

Provenance & Evidence