Methanol → HCID 69046386, compound

Participants

Reaction Steps

To the solution of 2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethyl-phenyl)pyrimidine (7.8 g) in a mixed solvent of methanol and water (200 ml, 10:1) was added OXONE (34 g). The mixture was stirred at room temperature for 3 hours, then, diluted with ethyl acetate (500 ml). The mixture was washed with water (3×500 ml). Organic layer dried over sodium sulphate, solvent removed under reduced pressure to give 2-methanesulphonyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)-pyrimidine (8.9 g) as crude product which was used for next step without further purification. 1H NMR (CDCl3): δ 8.3-8.4 (m, 2H), 7.8-7.87 (m, 2H), 7.68 (dd, 1H), 3.77 (t, 2H), 3.43 (s, 3H), 3.10 (t, 2H), 2.10 (m, 2H).

Provenance & Evidence