Triacetoxyperiodinane → HCID 86619632, compound

Participants

Reaction Steps

Dess-Martin periodinane (104 mg) was added to a solution of 4-(3-hydroxy-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile (50 mg) in dichloro-methane (5 mL), and the resulting suspension stirred at room temperature for 45 min. The mixture was then washed with water (3×10 mL), dried over sodium sulphate, and evaporated at reduced pressure to afford 4-(3-oxo-propyl)-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile as a brown solid (70 mg). MS m/z 306.1 (M+1), 100%.

Provenance & Evidence