Glycine → HCID 52947078, compound

Participants

Reaction Steps

To a stirred solution of 4-(3-oxo-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile (50 mg) in methanol (1 mL) was added glycine (25 mg), followed by water (100 μL) and acetic acid (12 μL). The mixture was stirred at room temperature for five minutes then solid supported cyanoborohydride (77 mg, 2.57 mmol/g) was added and stirring continued overnight. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to yield crude product. Purification by preparative-HPLC afforded the TFA salt of 4-[3-(carboxymethyl-amino)-propyl]-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile.

Provenance & Evidence