Acetic Acid → HCID 86619639, compound

Participants

Reaction Steps

To a solution of 4-(3-oxo-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile (153 mg) in methanol (2 ml) was added cyclopropylamine (140 μL), acetic acid (0.12 mL), and followed by sodium triacetoxyborohydride (210 mg). The mixture was stirred at room temperature for 24 hours, then purified by preparative-HPLC. 4-(3-cyclopropylamino-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile TFA salt was isolated as a white solid (70 mg).

Provenance & Evidence