関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 4-Isopropylbenzyl chloride | HCID 74916 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Isopropylphenylacetonitrile | HCID 138222 | 102.2% |
反応手順
To a stirred solution of 100 g of 4-isopropylbenzyl chloride in 1500 mL of N,N-dimethylformamide was added 32.0 g of sodium cyanide under ice-cooling. The mixture was stirred at 70° C. for 4 hours, and water was added to the reaction mixture. The mixture was extracted with ethyl acetate, and the organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 96.5 g of (4-isopropylphenyl)acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07589126B2 |
|---|
| 出典データセット | uspto-grants-2009_09 |
|---|
| ORD ID | ord-9f7b2648176948e5bdc7884edabb8adc |
|---|
| 出典メモ | uspto-grants-2009_09 |
|---|
