Sodium Hydroxide → Sodium [4-[2-(5-cyano-2-hydroxybenzenesulfonylamino)ethyl]-2'-methanesulfonylbiphenyl-3-yloxy]acetate

HRID 733377Notes

Reaction equation

HRID 733377 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:36])=[C:7]([S:9]([NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[S:27]([CH3:30])(=[O:29])=[O:28])=[CH:17][C:16]=2[O:31][CH2:32][C:33]([OH:35])=[O:34])(=[O:11])=[O:10])[CH:8]=1)#[N:2].[OH-].[Na+:38]>C(O)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:36])=[C:7]([S:9]([NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[S:27]([CH3:30])(=[O:29])=[O:28])=[CH:17][C:16]=2[O:31][CH2:32][C:33]([O-:35])=[O:34])(=[O:10])=[O:11])[CH:8]=1)#[N:2].[Na+:38]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 17856249[4-[2-(5-Cyano-2-hydroxybenzenesulfonylamino)ethyl]-2'-methanesulfonyl-biphenyl-3-yloxy]acetic acid

Product 1

HCID 23680380Sodium [4-[2-(5-cyano-2-hydroxybenzenesulfonylamino)ethyl]-2'-methanesulfonylbiphenyl-3-yloxy]acetate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 146 g of [4-[2-(5-cyano-2-hydroxybenzenesulfonylamino)ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetic acid in 580 mL of ethanol was added 137 mL of 2 mol/L sodium hydroxide solution under ice-cooling, and the solvent was removed under reduced pressure. The residue was suspended with 1.16 L of ethanol, and the mixture was stirred under reflux for an hour, then at room temperature overnight. The obtained white solid was collected by filtration to give 129 g of sodium [4-[2-(5-cyano-2-hydroxybenzenesulfonyl-amino)ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetate.

Workup

  1. temperaturecooling
  2. customthe solvent was removed under reduced pressure
  3. temperatureunder reflux for an hour
  4. customat room temperature
  5. customovernight
  6. filtrationThe obtained white solid was collected by filtration

Sources & evidence

ORD record
ord-25b38aa8c1024efbb8d242dd6d227c8b
Source dataset
uspto-grants-2009_09
Patent number
US07589126B2

Reaction notes

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