Hcl-butanol → HCID 178451322, compound

HRID 733379Notes

Reaction equation

HRID 733379 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[NH:11])[NH:9][OH:10])=[CH:4][C:3]=1[S:12]([NH:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[S:30]([CH3:33])(=[O:32])=[O:31])=[CH:20][C:19]=1[O:34][CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])(=[O:14])=[O:13].[CH2:41](O)[CH2:42]CC.[ClH:46]>>[ClH:46].[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[NH:11])[NH:9][OH:10])=[CH:4][C:3]=1[S:12]([NH:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[S:30]([CH3:33])(=[O:32])=[O:31])=[CH:20][C:19]=1[O:34][CH2:35][C:36]([O:38][CH2:39][CH2:40][CH2:41][CH3:42])=[O:37])(=[O:13])=[O:14]

Participants

3

Reactant 2

HCID 22990708Hcl-butanolHCID 178472948HCID 178472948, compound

Product 1

HCID 178451322HCID 178451322, compound

Procedure

Method 1) A solution of 1.499 g of ethyl [4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl)benzenesulfonylamino]-ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetate in 20 mL of 34% hydrogen chloride n-butanol solution was stirred at 60° C. for 3 hours. After being concentrated under reduced pressure, the reaction mixture was recrystallized from n-butanol-diisopropyl ether to give 1.472 g of n-butyl [4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl)benzenesulfonylamino]ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetate hydrochloride as a white crystal.

Workup

  1. concentrationAfter being concentrated under reduced pressure
  2. customthe reaction mixture was recrystallized from n-butanol-diisopropyl ether

Sources & evidence

ORD record
ord-efdbb6c55e1542f19432d8150d4f2dba
Source dataset
uspto-grants-2009_09
Patent number
US07589126B2

Reaction notes

Loading…