HRID733379

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22990708

未命名化合物

结构：CCOC(=O)COc1cc(-c2ccccc2S(C)(=O)=O)ccc1CCNS(=O)(=O)c1cc(C(=N)NO)ccc1O

HCID178472948

未命名化合物

PRODUCTS

生成物

结构：CCCCOC(=O)COc1cc(-c2ccccc2S(C)(=O)=O)ccc1CCNS(=O)(=O)c1cc(C(=N)NO)ccc1O.Cl

HCID178451322

未命名化合物

PROCEDURE

实验过程

Method 1) A solution of 1.499 g of ethyl [4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl)benzenesulfonylamino]-ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetate in 20 mL of 34% hydrogen chloride n-butanol solution was stirred at 60° C. for 3 hours. After being concentrated under reduced pressure, the reaction mixture was recrystallized from n-butanol-diisopropyl ether to give 1.472 g of n-butyl [4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl)benzenesulfonylamino]ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetate hydrochloride as a white crystal.

WORKUP

后处理

concentrationAfter being concentrated under reduced pressure
customthe reaction mixture was recrystallized from n-butanol-diisopropyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-efdbb6c55e1542f19432d8150d4f2dba
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07589126B2
来源说明: uspto-grants-2009_09

反应 SMILES

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[NH:11])[NH:9][OH:10])=[CH:4][C:3]=1[S:12]([NH:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[S:30]([CH3:33])(=[O:32])=[O:31])=[CH:20][C:19]=1[O:34][CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])(=[O:14])=[O:13].[CH2:41](O)[CH2:42]CC.[ClH:46]>>[ClH:46].[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[NH:11])[NH:9][OH:10])=[CH:4][C:3]=1[S:12]([NH:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[S:30]([CH3:33])(=[O:32])=[O:31])=[CH:20][C:19]=1[O:34][CH2:35][C:36]([O:38][CH2:39][CH2:40][CH2:41][CH3:42])=[O:37])(=[O:13])=[O:14]