Dimethylformamide → HCID 178419502, compound

Participants

Reaction Steps

By analogy with Example 2, 0.7 g (3.3 mmol) of 3-bromo-6-methyl-1H-pyrazolo[3,4-b]pyridine is reacted with 1.1 g (9.9 mmol) of 1,4-diazabicyclo[3.2.1]octane in the presence of 0.35 g (0.5 mmol) of bis(triphenylphosphino)dichloropalladium and 2.3 ml of triethylamine in 10 ml of dimethylformamide under the conditions described for Example 1, giving 0.21 g of product, which is dissolved in 20 ml of acetone before addition of 0.27 ml of a 5.7 N solution of hydrobromic acid in acetic acid. The dihydrobromide crystals are collected by filtration and dried under vacuum.

Provenance & Evidence