9-(8-azabicyclo[3.2.1]octan-3-ylidene)-N,N-diethylxanthene-3-carboxamide → 3-(3-Bromo-9H-xanthen-9-yl)-8-aza-bicyclo[3.2.1]octane

HRID 733392Notes

Reaction equation

HRID 733392 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[C:16]3[CH2:22][CH:21]4[NH:23][CH:18]([CH2:19][CH2:20]4)[CH2:17]3)[C:7]3[C:12]([O:13][C:14]=2[CH:15]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3.C(N(CC)C(C1C=CC2C(=C3CC4NC(CC4)C3)C3C(OC=2C=1)=CC=CC=3)=O)C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:6]([CH:16]3[CH2:22][CH:21]4[NH:23][CH:18]([CH2:19][CH2:20]4)[CH2:17]3)[C:7]3[C:12]([O:13][C:14]=2[CH:15]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3

Participants

3

Reactant 2

HCID 469181419-(8-azabicyclo[3.2.1]octan-3-ylidene)-N,N-diethylxanthene-3-carboxamide2×HCID 578392193-(3-Bromo-xanthen-9-ylidene)-8-aza-bicyclo[3.2.1]octane

Product 1

HCID 578392693-(3-Bromo-9H-xanthen-9-yl)-8-aza-bicyclo[3.2.1]octane

Procedure

Using an adaptation of the method described in Procedure 9, substituting 3-(3-bromo-xanthen-9-ylidene)-8-aza-bicyclo[3.2.1]octane, 1b for 9-(8-aza-bicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide, 8a, the title compound 3-(3-bromo-9H-xanthen-9-yl)-8-aza-bicyclo[3.2.1]octane, 2b was obtained. MS m/z=370.0/372.0 (MH+).

Sources & evidence

ORD record
ord-4611f29424a347dfaeece51d19c9c8b6
Source dataset
uspto-grants-2009_09
Patent number
US07589104B2

Reaction notes

Loading…