Methyl 9-oxoxanthene-3-carboxylate → 7-Fluoro-9-oxo-9H-xanthene-3-carboxylic acid

HRID 733401Notes

Reaction equation

HRID 733401 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[C:9](=[O:20])[C:10]3[C:15]([O:16][C:17]=2[CH:18]=1)=[CH:14][CH:13]=[C:12]([F:19])[CH:11]=3)=[O:4].COC(C1C=CC2C(=O)C3C(OC=2C=1)=CC=CC=3)=O>>[F:19][C:12]1[CH:11]=[C:10]2[C:15]([O:16][C:17]3[CH:18]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=[CH:7][C:8]=3[C:9]2=[O:20])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 473475Methyl 9-oxoxanthene-3-carboxylate2×HCID 578392387-Fluoro-9-oxo-9H-xanthene-3-carboxylic acid methyl ester

Product 1

HCID 578392377-Fluoro-9-oxo-9H-xanthene-3-carboxylic acid

Procedure

Using an adaptation of the method described in Procedure 5, substituting 7-fluoro-9-oxo-9H-xanthene-3-carboxylic acid methyl ester, 2e for 9-oxo-9H-xanthene-3-carboxylic acid methyl ester, 4a, the title compound 7-fluoro-9-oxo-9H-xanthene-3-carboxylic acid, 3e was obtained. MS m/z (MH+) 258.9.

Sources & evidence

ORD record
ord-6872019680bb4f5591ddcdb83794604a
Source dataset
uspto-grants-2009_09
Patent number
US07589104B2

Reaction notes

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