HuagongsheHuagongshe Chemistry Print Report · For research reference only
9-(8-Aza-bicyclo[3.2.1]oct-3-ylidene)-5-bromo-9H-xanthene-3-carboxylic acid diethylamide → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9-(8-Aza-bicyclo[3.2.1]oct-3-ylidene)-5-bromo-9H-xanthene-3-carboxylic acid diethylamide | HCID 46917940 | — |
| Reactant | 7-Fluoro-9-[8-(2,2,2-trifluoro-acetyl)-8-aza-bicyclo[3.2.1]oct-3-ylidene]-9H-xanthene-3-carboxylic acid diethylamide | HCID 57839249 | — |
| Reactant | 5-Methoxy-9-[8-(2,2,2-trifluoro-acetyl)-8-aza-bicyclo[3.2.1]oct-3-ylidene]-9H-xanthene-3-carboxylic acid diethylamide | HCID 57839262 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | 9-(8-Aza-bicyclo[3.2.1]oct-3-ylidene)-7-fluoro-9H-xanthene-3-carboxylic acid diethylamide | HCID 11304318 | — |
Reaction Steps
Using an adaptation of the method described in Procedure 17, substituting 7-fluoro-9-[8-(2,2,2-trifluoro-acetyl)-8-aza-bicyclo[3.2.1]oct-3-ylidene]-9H-xanthene-3-carboxylic acid diethylamide, 5e for 5-methoxy-9-[8-(2,2,2-trifluoro-acetyl)-8-aza-bicyclo[3.2.1]oct-3-ylidene]-9H-xanthene-3-carboxylic acid diethylamide, 5d, the title compound 9-(8-aza-bicyclo[3.2.1]oct-3-ylidene)-7-fluoro-9H-xanthene-3-carboxylic acid diethylamide, 6e was obtained as TFA salt after reverse phase HPLC purification (eluent gradient: CH3CN in H2O containing 0.1% TFA). MS m/z (MH+) 407.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07589104B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-ff6013232eb14545bc366b0a3461919d |
| Source note | uspto-grants-2009_09 |