HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 1-[3-(3-Bromo-9H-xanthen-9-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-2,2,2-trifluoroethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 9-(8-azabicyclo[3.2.1]octan-3-ylidene)-N,N-diethylxanthene-3-carboxamide | HCID 46918141 | — |
| Reactant | 1-[3-(3-Bromoxanthen-9-ylidene)-8-aza-bicyclo[3.2.1]oct-8-yl]-2,2,2-trifluoroethanone | HCID 57725312 | — |
| Solvent | Heptane | HCID 8900 | — |
| Product | 1-[3-(3-Bromo-9H-xanthen-9-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-2,2,2-trifluoroethanone | HCID 57839265 | — |
Reaction Steps
Using an adaptation of the method described in Procedure 9, substituting 1-[3-(3-bromoxanthen-9-ylidene)-8-aza-bicyclo[3.2.1]oct-8-yl]-2,2,2-trifluoro-ethanone, 1j for 9-(8-aza-bicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide, 8a, the title compound 1-[3-(3-bromo-9H-xanthen-9-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-2,2,2-trifluoro-ethanone, 2j was obtained after puirification via flash column chromatography (eluent gradient: 5% to 25% EtOAc in heptane). MS m/z (MH+) 465.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07589104B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-e9f860a73aaa4b88929428ea6d1ad73c |
| Source note | uspto-grants-2009_09 |