Sodium Hydroxide → HCID 178419905, compound

Participants

Reaction Steps

To a solution of 2,2,2-trifluoro-1-{3-[3-(1H-tetrazol-5-yl)-9H-xanthen-9-yl]-8-aza-bicyclo[3.2.1]oct-8-yl}-ethanone, 4j (0.33 g, 0.724 mmol) in methanol (10 mL) was added a 1N NaOH solution (2.17 mmol, 2.17 mL), and the mixture was heated to reflux for 1 h. The mixture was allowed to cool to rt and evaporated. The residue was purified via reverse phase HPLC (eluent gradient: CH3CN in H2O containing 0.1% TFA) to yield 0.22 g (64%) of title compound 3-[3-(1H-tetrazol-5-yl)-9H-xanthen-9-yl]-8-aza-bicyclo[3.2.1]octane, 5j as a TFA salt. MS m/z (MH+) 360.1.

Provenance & Evidence