HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(2,2,2-Trifluoroacetyl)-8-azabicyclo[3.2.1]octan-3-one → 1-[3-(3-Bromo-5-methoxy-xanthen-9-ylidene)-8-aza-bicyclo[3.2.1]oct-8-yl]-2,2,2-trifluoro-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(2,2,2-Trifluoroacetyl)-8-azabicyclo[3.2.1]octan-3-one | HCID 15252306 | — |
| Reactant | N,N-Diethyl-9-oxo-9H-xanthene-3-carboxamide | HCID 15953972 | — |
| Reactant | 3-Bromo-5-methoxy-xanthen-9-one | HCID 57436669 | — |
| Product | 1-[3-(3-Bromo-5-methoxy-xanthen-9-ylidene)-8-aza-bicyclo[3.2.1]oct-8-yl]-2,2,2-trifluoro-ethanone | HCID 57725349 | — |
Reaction Steps
Using an adaptation of the method described in Procedure 7, substituting 3-bromo-5-methoxy-xanthen-9-one, 3k for 9-oxo-9H-xanthene-3-carboxylic acid diethylamide, 6a and 8-(2,2,2-trifluoro-acetyl)-8-aza-bicyclo[3.2.1]octan-3-one for N-carbethoxynortropinone, the title compound 1-[3-(3-bromo-5-methoxy-xanthen-9-ylidene)-8-aza-bicyclo[3.2.1]oct-8-yl]-2,2,2-trifluoro-ethanone, 4k was obtained. MS m/z (MH+) 467.7, 469.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07589104B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-c7a5645c0dc846fd9a5ad60774b13589 |
| Source note | uspto-grants-2009_09 |