Octanoic acid, 2-(2-propynyl)-, (2R)- → (R)-(-)-2-propyloctanoic acid

Participants

Reaction Steps

Additionally, it is also possible in the above reaction steps that, for example, in the step (A), a two-carbon adding reaction is carried out using an unsaturated organic metal reagent (e.g., vinyl magnesium chloride, vinyl magnesium bromide, ethynyl magnesium chloride, ethynyl magnesium bromide, etc.) as an organic metal reagent, the resulting (4R)-1-decen-4-ol or (4R)-1-decyn-4-ol is subjected to the reactions of the step (B) or the step (C), and the resulting (2R)-(2-propenyl)octanoic acid or (2R)-(2-propynyl)octanoic acid is reduced by the method mentioned in WO 99/58513 and WO 00/48982 to give (2R)-2-propyloctanoic acid of high purity.

Provenance & Evidence