Methanol → HCID 131727635, compound

Participants

Reaction Steps

To a mixture of 4-(N-Boc-aminomethyl) cinnamic acid (5 g, 0.018 mol) in methanol (200 mL) was added thionylchloride (11 g) at 0° C. and slowly heated to reflux for 3 h. The reaction mixture was concentrated to give solid product. The solid hydrochloride salt was washed with EtOAc and filtered off to give the title compound (3.5 g, 86%).

Provenance & Evidence