Cinnamoyl Chloride → methyl [4-({(4-dec-1-ynylbenzyl)[(2E)-3-phenylprop-2-enoyl]amino}methyl)phenoxy]acetate

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Reaction Steps

The title compound was prepared following the procedure E using methyl (4-{[(4-dec-1-ynylbenzyl)amino]methyl}phenoxy)acetate and (2E)-3-phenylacryloyl chloride (purification by flash chromatography on SiO2-c-Hex/EtOAc 9:1) as a colorless oil (64%). M+ (ESI): 552.1. HPLC, Rt: 6.1 min (purity: 99.5%). 1H NMR (CDCl3) δ: 7.85 (m, 1H), 7.47-7.12 (m, 11H), 6.90 (m, 3H), 4.65-4.52 (m, 6H), 3.82 (s, 3H), 2.41 (t, J=7.0 Hz, 2H), 1.61 (m, 2H), 1.45 (m, 2H), 1.30 (m, 8H), 0.89 (t, J=6.8 Hz, 3H).

Provenance & Evidence