3-Cyclopentylpropionyl chloride → Methyl 3-(4-{[(3-cyclopentylpropanoyl)(4-dec-1-ynylbenzyl)-amino]methyl}phenyl)propanoate

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The title compound was prepared following the procedure E using of methyl 3-(4-{[(4-dec-1-ynylbenzyl)amino]methyl}phenyl)propanoate and 3-cyclopentylpropanoyl chloride (purification by flash chromatography on SiO2. EtOAc/c-Hex 1/1) as a colorless oil (81%). 1H NMR (CDCl3) δ: 7.35-6.93 (m, 8H), 4.47 (s, 2H), 4.34 (s, 1H), 4.31 (s, 1H), 3.61 and 3.60 (2 s, 3H) 2.88 (q, J=7.9 Hz, 2H), 2.55 (q, J=7.2 Hz, 2H), 2.41-2.20 (m, 4H), 1.78-1.12 (m, 21H), 1.10-0.91 (m, 2H), 0.88-0.75 (m, 3H). M+ (ESI): 544.1. HPLC, Rt: 6.6 min (purity: 93.8%).

Provenance & Evidence