Sodium Hydroxide → 5-[{4-[(4-Butylphenyl)ethynyl]benzyl)(cyclohexylcarbonyl)amino]-2-hydroxybenzoic acid

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Reaction Steps

The titled compound was prepared following the procedure C using N-{4-[(4-butylphenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)cyclohexanecarboxamide and NaOH (1N) in the presence of EtOH as a white powder (42%). 1H NMR (DMSO-d6, 300 MHz) δ 7.44 (m, 5H), 7.27-7.16 (m, 5H), 6.95 (d, J=8.7 Hz, 1H), 4.79 (s, 2H), 2.59 (t, J=7.8 Hz, 2H), 2.12 (m, 1H), 1.63-0.89 (m, 14H), 0.88 (t, J=7.4 Hz, 3H). M− (ESI): 508.3; M+ (ESI): 509.7. HPLC, Rt: 5.58 min (Purity: 99.8%).

Provenance & Evidence