4-tert-Butylbenzoyl chloride → 4-tert-butyl-N-{4-[(4-butylphenyl)ethynyl]benzyl)-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)benzamide

Participants

Reaction Steps

The titled compound was prepared following the procedure J using 6-({4-[(4-butylphenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one hydrochloride and 4-tert-butylbenzoyl chloride as a colorless oil (76%). 1H NMR (CDCl3, 300 MHz) δ 7.65 (d, J=2.3 Hz, 1H), 7.46 (m, 4H), 7.30-7.16 (m, 8H), 7.01 (dd, J=8.7, 2.3 Hz, 1H), 6.74 (d, J=8.7 Hz, 1H), 5.14 (s, 2H), 2.64 (t, J=7.7 Hz, 2H), 1.68 (s, 6H), 1.62 (m, 2H), 1.38 (m, 2H), 1.25 (s, 9H), 0.95 (t, J=7.2 Hz, 3H). HPLC, Rt: 6.12 min (Purity: 97%).

Provenance & Evidence