Sodium Hydroxide → 5-((Biphenyl-4-ylcarbonyl){4-[(4-butylphenyl)ethynyl]benzyl}amino)-2-hydroxybenzoic acid

HRID 733548Notes

Reaction equation

HRID 733548 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:47]=[CH:46][C:16]([CH2:17][N:18]([C:33]3[CH:45]=[CH:44][C:36]4[O:37]C(C)(C)[O:39][C:40](=[O:41])[C:35]=4[CH:34]=3)[C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[CH:23][CH:22]=3)=[O:20])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>CCO>[C:24]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:25]=[CH:26][C:21]([C:19]([N:18]([CH2:17][C:16]2[CH:46]=[CH:47][C:13]([C:12]#[C:11][C:8]3[CH:7]=[CH:6][C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[CH:10][CH:9]=3)=[CH:14][CH:15]=2)[C:33]2[CH:45]=[CH:44][C:36]([OH:37])=[C:35]([CH:34]=2)[C:40]([OH:41])=[O:39])=[O:20])=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57841342N-{4-[(4-butylphenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)biphenyl-4-carboxamide

Product 1

HCID 113191795-((Biphenyl-4-ylcarbonyl){4-[(4-butylphenyl)ethynyl]benzyl}amino)-2-hydroxybenzoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The titled compound was prepared following the procedure C using N-{4-[(4-butylphenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)biphenyl-4-carboxamide and NaOH 1M aq. in the presence of EtOH as a pale yellow powder (41%).

Sources & evidence

ORD record
ord-7d24a13099874a8bb6ac7bb27da32f1c
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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