HRID733548

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCCCc1ccc(C#Cc2ccc(CN(C(=O)c3ccc(-c4ccccc4)cc3)c3ccc4c(c3)C(=O)OC(C)(C)O4)cc2)cc1

HCID57841342

未命名化合物

PRODUCTS

生成物

结构：CCCCc1ccc(C#Cc2ccc(CN(C(=O)c3ccc(-c4ccccc4)cc3)c3ccc(O)c(C(=O)O)c3)cc2)cc1

HCID11319179

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

The titled compound was prepared following the procedure C using N-{4-[(4-butylphenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)biphenyl-4-carboxamide and NaOH 1M aq. in the presence of EtOH as a pale yellow powder (41%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7d24a13099874a8bb6ac7bb27da32f1c
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07589232B2
来源说明: uspto-grants-2009_09

反应 SMILES

[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:47]=[CH:46][C:16]([CH2:17][N:18]([C:33]3[CH:45]=[CH:44][C:36]4[O:37]C(C)(C)[O:39][C:40](=[O:41])[C:35]=4[CH:34]=3)[C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[CH:23][CH:22]=3)=[O:20])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>CCO>[C:24]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:25]=[CH:26][C:21]([C:19]([N:18]([CH2:17][C:16]2[CH:46]=[CH:47][C:13]([C:12]#[C:11][C:8]3[CH:7]=[CH:6][C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[CH:10][CH:9]=3)=[CH:14][CH:15]=2)[C:33]2[CH:45]=[CH:44][C:36]([OH:37])=[C:35]([CH:34]=2)[C:40]([OH:41])=[O:39])=[O:20])=[CH:22][CH:23]=1