Sodium Hydroxide → HCID 11353321, compound

Participants

Reaction Steps

The titled compound was prepared following the procedure C using 2-(benzyloxy)-N-{4-[(4-butylphenyl)ethynyl]benzyl}-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-6-yl)acetamide and NaOH 5M aq. in die presence of EtOH as a beige powder (67%). 1H NMR (CDCl3, 300 MHz) δ 10.76 (s, 1H), 7.53 (m, 1H), 7.43 (m, 4H), 7.28 (m, 5H), 7.17 (m, 4H), 6.98 (m, 1H), 6.90 (d, J=8.7 Hz, 1H), 4.88 (s, 2H), 4.56 (s, 2H), 3.91 (s, 2H), 2.62 (t, J=7.7 Hz, 2H), 1.61 (m, 2H), 1.37 (m, 2H), 0.93 (t, J=7.4 Hz, 3H). M− (ESI): 546.2; M+ (ESI): 548.3. HPLC, Rt; 5.33 min (Purity: 99%).

Provenance & Evidence