Sodium Hydroxide → 4-[{4-[(4-Butylphenyl)ethynyl]benzyl}(3-cyclopentylpropanoyl)amino]-2-hydroxybenzoic acid

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Reaction Steps

The titled compound was prepared following the procedure C using N-{4-[(4-butylphenyl)ethynyl]benzyl}-3-cyclopentyl-N-(2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-7-yl)propanamide and NaOH as a yellow powder (74%). 1H NMR (DMSO-d6, 300 MHz) δ 7.76 (d, J=8.3 Hz, 1H), 7.45 (m, 4H), 7.23 (m, 4H) 6.84 (m, 1H), 6.77 (m, 1H), 4.92 (s, 2H), 2.60 (t, J=7.6 Hz, 2H), 2.20 (t, J=7.3 Hz, 2H), 1.70-1.21 (m, 13H), 1.00-0.84 (m, 5H). HPLC, Rt: 5.84 min (Purity: 100%).

Provenance & Evidence