Hexanoyl chloride → HCID 86612442, compound

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Reaction Steps

The titled compound was prepared following the procedure B using methyl {4-[({4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]phenoxy}acetate and hexanoyl chloride as a colorless oil (79%). 1H NMR (CDCl3, 300 MHz) δ 7.41-7.50 (m, 4H), 7.03-7.16 (m, 6H), 6.85 (m, 2H), 4.62 (s, 1H), 4.60 (s, 1H), 4.55 (s, 1H), 4.51 (s, 1H), 4.41 (s, 1H), 4.36 (s, 1H), 3.80 (s, 1.5H), 3.79 (s, 1.51, 2.60 (t, J=7.6 Hz, 2H), 2.38 (m, 2H), 1.56-1.67 (m, 4H), 1.30-1.37 (m, 6H), 0.91 (m, 6H). M+ (ESI): 540.4. HPLC, Rt: 5.85 min (Purity: 99.3%).

Provenance & Evidence