Sodium Hydroxide → HCID 11215259, compound

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The titled compound was prepared following the procedure F using methyl (4-{[{4-[(4-butylphenyl)ethynyl]benzyl}(1H-indazol-3-ylcarbonyl)amino]methyl}phenoxy)acetate and NaOH 1N in the presence of MeOH/THF, as a yellow oil (75%). 1H NMR (MeOD, 300 MHz) δ 8.09 (m, 1H), 7.17-7.64 (m, 13H), 6.90 (m, 2H), 5.07 (s, 1H), 5.02 (s, 1H), 4.67 (m, 4H), 2.62 (t, J=7.6 Hz, 2H), 1.61 (m, 2H), 1.35 (m, 2H), 0.95 (t, J=7.3 Hz, 3H). M− (ESI): 570.3; M+ (ESI): 572.3. HPLC, Rt: 5.16 min (Purity: 94.1%).

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