Sodium Hydroxide → HCID 178440832, compound

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Reaction Steps

The titled compound was prepared following the procedure F using methyl [4-({{4-[(4-butylphenyl)ethynyl]benzyl}[(6-hydroxypyridin-3-yl)carbonyl]amino}methyl)phenoxy]acetate and NaOH 1N in the presence of MeOH/THF as a white powder (47%). 1H NMR (DMSO-d6, 300 MHz) δ 7.57-7.43 (m, 6H), 7.26-7.09 (m, 6H), 6.89 (d, J=8.7 Hz, 2H), 6.33 (d, J=9.4 Hz, 1H), 4.65 (s, 2H), 4.52 (2H), 4.48 (s, 2H), 2.60 (t, J=7.5 Hz, 2H), 1.55 (m, 2H), 1.30 (m, 2H), 0.89 (t, J=7.3 Hz, 3H). M− (ESI): 547.3; M+ (ESI): 549.4. HPLC, Rt: 4.48 min (Purity: 76.9%).

Provenance & Evidence