Sodium Hydroxide → (4-{[{4-[(4-butylphenyl)ethynyl]benzyl}(1H-pyrazol-4-ylcarbonyl)amino]methyl}phenoxy)acetic acid

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The titled compound was prepared following the procedure F using methyl (4-{[{4-[(4-butylphenyl)ethynyl]benzyl}(1H-pyrazol-4-ylcarbonyl)amino]methyl}phenoxy)acetate and NaOH 1N in the presence of MeOH/THF as a white powder (30%). 1H NMR (MeOD, 300 MHz) δ 7.76 (m, 2H), 7.45 (m, 4H), 7.17 (m, 6H), 6.88 (m, 2H), 4.64 (s, 2H), 3.94 (s, 4H), 2.59 (t J=7.7 Hz, 2H), 1.57 (m, 2H), 1.33 (m, 2H), 0.90 (t, J=7.3 Hz, 3H). HPLC, Rt: 4.62 min (Purity: 88%).

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