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Sodium Hydroxide → 4-[((4-Tert-butylbenzoyl){4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-Cyclopentylpropionyl chloride | HCID 66039 | — |
| 反応物 | Methyl 4-[((4-tert-butylbenzoyl){4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]benzoate | HCID 57841411 | — |
| 生成物 | 4-[((4-Tert-butylbenzoyl){4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]benzoic acid | HCID 11295907 | — |
反応手順
The titled compound was prepared following the procedure F using methyl 4-[((4-tert-butylbenzoyl){4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]benzoate and NaOH 5M in the presence of MeOH/THF 1/1, as a brown solid (95%). 1H NMR (CDCl3, 300 MDz) δ 8.09 (d, 2H, J=7.9 Hz), 7.54-7.32 (m, 6H), 7.22-7.09 (m, 4H), 4.79-4.42 (m, 4H), 2.62 (t, 2H, J=7.7 Hz), 1.70-1.05 (m, 14H), 0.97-0.75 (m, 6H). M− (ESI): 556.3; M+ (ESI): 558.4. HPLC, Rt: 6.03 min (Purity: 98.8%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07589232B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-dbc827f716cb47f89bfc6dc48ee6b5e9 |
| 出典メモ | uspto-grants-2009_09 |