Lithium hydroxide, monohydrate → HCID 57841314, compound

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The titled compound was prepared following the procedure F using ethyl 4-[{4-[(4-butylphenyl)ethynyl]benzyl}(3-cyclopentylpropanoyl)amino]benzoate and LiOH.H2O in the presence of dioxane as a yellow powder (79%). 1H NMR (CDCl3, 300 MHz) δ 8.08 (m, 2H), 7.49-7.35 (m, 4H), 7.23-7.02 (m, 6H), 4.91 (br s, 2H), 2.66-2.53 (m, 2H), 2.18-2.05 (m, 2H), 1.70-1.20 (m, 13H), 1.30-0.82 (m, 5H). M− (ESI): 506.4; M+ (ESI): 508.4. HPLC, Rt: 5.67 min (Purity: 98.5%).

Provenance & Evidence