4-[(4-Chlorophenyl)ethynyl]benzaldehyde → 6-({4-[(4-chlorophenyl)ethynyl]benzyl}amino)-2,2-dimethyl-4H-1,3-benzodioxin-4-one

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Reaction Steps

The titled compound was prepared following the procedure A using 4-[(4-chlorophenyl)ethynyl]benzaldehyde (intermediate which may be obtained according to methods disclosed in EP03103780.7) and 6-amino-2,2-dimethyl-4H-1,3-benzodioxin-4-one as a yellow powder (62%). 1H NMR (CDCl3, 300 MHz) δ 7.52-7.41 (m, 4H), 7.38-7.28 (m, 4H), 7.16 (d, J=2.7 Hz, 1H), 6.87-6.76 (m, 2H), 4.34 (s, 2H), 1.68 (s, 6H). M− (ESI): 416.1. HPLC, Rt: 5.45 min (Purity: 96%).

Provenance & Evidence